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Endocrine Abstracts

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ea0099p32 | Adrenal and Cardiovascular Endocrinology | ECE2024

Physical activity after planned cessation of prednisolone treatment in patients with polymyalgia rheumatica and/or giant cell arteritis: baseline data from the double edge-replace study

Stankovic Jelena , Lund MarieLouise , Dreyer AnjaFenger , Al-Jorani Hajir , Boesen Victor Brun , Borresen StinaWillemoes , Christensen LouiseLehmann , Feldt-Rasmussen Ulla , Glintborg Dorte , Hansen Simon Boggild , Jensen Richard Christian , Jorgensen NannaThurmann , Bislev LiseSofie , Tei Randi , Andersen Marianne , Jorgensen JensOtto

Introduction: Myopathy is a known and dreaded adverse effect of pharmacological glucocorticoid (GC) treatment, but its impact on daily physical activity is not known.Aim: To measure spontaneous physical activity and musculoskeletal function in patients shortly after planned cessation of long-term (>12 weeks) prednisolone treatment.Patients and methods: Baseline data from an ongoing nation-wide prospective study (DOUBLE EDGE &#1...
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ea0090ep23 | Adrenal and Cardiovascular Endocrinology | ECE2023

REPLACE: Effect of hydrocortisone and placebo in patients with partial adrenal insufficiency after cessation of glucocorticoid treatment; A study protocol for a multi-centre, randomised, double-blinded, placebo-controlled clinical trial

Dreyer Anja Fenger , Borresen Stina Willemoes , Hansen Simon Boggild , Al-Jorani Hajir , Bislev Lise Sofie , Boesen Victor Brun , Christensen Louise Lehmann , Glintborg Dorte , Jensen Richard Christian , Jorgensen Nanna Thurmann , Klose Marianne , Lund Marie Louise , Stankovic Jelena , Tei Randi , Watt Torquil , Feldt-Rasmussen Ulla , Jorgensen Jens Otto , Andersen Marianne

Background: Glucocorticoid (GC) formulations are widely used as anti-inflammatory treatment, and synthetic GC, e.g. prednisolone, is the cornerstone treatment of polymyalgia rheumatic (PMR) and giant cell arteritis (GCA). Long-term pharmacological GC treatment may induce adrenal insufficiency (GIA). Adrenal function is, however, not routinely assessed after discontinuation of long-term GC treatment, and it is unknown, if hydrocortisone replacement is beneficial. This study aim...
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ea0099p228 | Adrenal and Cardiovascular Endocrinology | ECE2024

Impact of glucocorticoid-induced adrenal insufficiency on health-related quality of life in patients receiving long-term low dose prednisolone treatment: Results from the double edge-rescue trial

Lund Marie Louise , Al-Jorani Hajir , Stankovic Jelena , Bislev Lise Sofie , Bjorner Jakob Bue , Boesen Victor Brun , Christensen Louise Lehmann , Feldt-Rasmussen Ulla , Dreyer Anja Fenger , Glintborg Dorte , Hansen Annette , Hansen Simon Boggild , Jensen Richard Christian , Jorgensen Nanna Thurmann , Klose Marianne , Locht Henning , Tei Randi , Watt Torquil , Stewart Paul M. , Sorensen Henrik Toft , Jorgensen Jens Otto , Andersen Marianne , Borresen Stina Willemoes

Objectives: The clinical impact of glucocorticoid-induced adrenal insufficiency in patients on low-dose prednisolone is unclear. We investigated the influence of adrenal function on health-related quality of life (HRQoL) in patients tapering prednisolone.Method: Baseline data from an ongoing prospective randomised clinical trial including 278 patients with polymyalgia rheumatica/giant cell arteritis treated with prednisolone for ≥12 weeks, current ...
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ea0099p238 | Adrenal and Cardiovascular Endocrinology | ECE2024

Musculoskeletal health and body composition in patients discontinuing long-term prednisolone treatment – prospective data from the replace Study

Bislev Lise Sofie , Lund Marie Louise , Dreyer Anja Fenger , Al-Jorani Hajir , Boesen Victor Brun , Borresen Stina Willemoes , Christensen Louise Lehmann , Feldt-Rasmussen Ulla , Glintborg Dorte , Hansen Simon Boggild , Jensen Richard Christian , Jorgensen Nanna Thurmann , Stankovic Jelena , Tei Randi , Andersen Marianne Skovsager , Klose Marianne , Jorgensen Jens OttoLunde

Background: Pharmacological glucocorticoid (GC) treatment exerts adverse effects on musculoskeletal health and may induce glucocorticoid-induced adrenal insufficiency (GIA), but these features have so far not been characterized in a prospective and unbiased manner.Aim: To characterize a population, who recently discontinued long-term (>12 weeks) prednisolone treatment with particular emphasis on the presence or absence of symptoms.<p class="abste...
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ea0099p413 | Adrenal and Cardiovascular Endocrinology | ECE2024

Glucocorticoid-induced adrenal insufficiency in patients with polymyalgia rheumatica and giant cell arteritis during long-term low-dose prednisolone treatment: Prediction based on indicators of exogenous hypercortisolism in the Double Edge Study

Jorgensen Nanna Thurmann , Stankovic Jelena , Dreyer Anja Fenger , Al-Jorani Hajir , Bislev Lise Sofie , Boesen Victor Brun , Borresen Stina Willemoes , Christensen Louise Lehmann , Feldt-Rasmussen Ulla , Glintborg Dorte , Gorlen Tanja Fromberg , Hansen Simon Boggild , Hetland Merete Lund , Jensen Bente , Jensen Richard Christian , Lund Marie Louise , Stewart Paul M , Tei Randi , Andersen Marianne , Jorgensen Jens Otto , Klose Marianne

Background and aim: Identifying patients with glucocorticoid-induced adrenal insufficiency poses a challenge. We investigated whether factors associated with exogenous hypercortisolism (as a proxy of overall elevated glucocorticoid exposure) could predict the risk of glucocorticoid-induced adrenal insufficiency in patients with polymyalgia rheumatica and/or giant cell arteritis during long-term low-dose prednisolone treatment.Material and methods: Baseli...
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ea0099p426 | Adrenal and Cardiovascular Endocrinology | ECE2024

Evaluation of quality of life by AddiQoL-30 compared to SF-36 in patients with previous long-term prednisolone treatment

Al-Jorani Hajir , Borresen Stina Willemoes , Bislev Lise Sofie , Jensen Richard Christian , Dreyer Anja Fenger , Hansen Simon Boggild , Boesen Victor Brun , Christensen Louise Lehmann , Glintborg Dorte , Jorgensen Nanna Thurmann , Klose Marianne , Lund Marie Louise , Stankovic Jelena , Tei Randi , Feldt-Rasmussen Ulla , Jorgensen Jens Otto , Andersen Marianne

Background: Long-term prednisolone therapy may lead to subtle changes in circadian oscillations of the hypothalamic-pituitary-adrenal axis, which can affect quality of life of the patient. Low score of the Addison’s disease-specific quality-of-life questionnaire (AddiQoL-30) could be a method to assess functional glucocorticoid-induced adrenal insufficiency.Objective: To compare scores from AddiQoL-30 with generic Short Form (SF-36) questionnaire in...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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